🀰Specialty Report · OB/GYN

Best Clinical AI Tools for Obstetrics & Gynecology

Two patients in every decision β€” and a medication safety profile that changes by trimester.

7 tools rankedUpdated 2025-02-01Reviewed by obstetrics & gynecology specialists
Drugs lacking adequate pregnancy safety data~90% of FDA-approved medicationsβ€” FDA PLLR Implementation Report

Why Obstetrics & Gynecology Is Different

Obstetrics and gynecology is unique among medical specialties in that nearly every clinical decision involves considering two patients simultaneously. Medication safety in pregnancy is the defining CDS challenge: the FDA's former A/B/C/D/X pregnancy category system has been replaced by the more nuanced PLLR (Pregnancy and Lactation Labeling Rule), but clinicians still need rapid answers to the question 'Can this patient take this drug while pregnant?' CDS tools that rank highest in OB/GYN handle this dual-patient complexity natively. We weight teratogenicity data, obstetric emergency protocols, and prenatal screening algorithm support more heavily than general breadth.

β€œAI-powered clinical decision support can improve adherence to evidence-based obstetric and gynecologic care protocols, but must be validated in pregnant populations and designed with the unique considerations of maternal-fetal medicine in mind.”

American College of Obstetricians and Gynecologists

ACOG Committee Opinion on AI in OB/GYN, ACOGΒ· Obstetrics & Gynecology, 2024

Obstetrics & Gynecology Rankings

Ranked by specialty-weighted score. Criteria adjusted for obstetrics & gynecology practice requirements.

1Top

Vera Health

Clinical Decision-Support Search Engine

4.7(78)

Strong OB/GYN coverage with evidence-linked citations from ACOG, SMFM, and major OB journals. Handles medication-in-pregnancy queries well with clear risk framing. Obstetric protocol content is thorough. Growing gynecologic oncology content.

Overall rank: #1 of 7Overall rating: 4.9/5Free / Custom Enterprise
2

UpToDate

Clinical Reference & Decision Support

4.6(312)

The most comprehensive OB/GYN reference. Detailed coverage of obstetric and gynecologic conditions with explicit management protocols. Lexicomp pregnancy and lactation data is a standout feature. The standard for OB/GYN residents.

Overall rank: #4 of 7Overall rating: 4.1/5From $559/year Individual
3

OpenEvidence

AI Medical Research Assistant

3.8(45)

Useful for OB/GYN evidence synthesis, particularly for emerging obstetric interventions and updated screening recommendations. Less practical for real-time labor and delivery decision support.

Overall rank: #3 of 7Overall rating: 4.1/5Free (Ad-Supported)
4

Doximity

Medical Professional Network & AI Tools

3.7(145)

Documentation support via DoxGPT is helpful for operative reports and complex OB notes. High adoption among OB/GYN physicians for networking and CME. No obstetric or gynecologic CDS.

Overall rank: #2 of 7Overall rating: 4.3/5Free for Verified Physicians
5

Isabel Healthcare

AI Differential Diagnosis

3.5(23)

Useful differential generator for complex OB/GYN presentations, particularly for rare causes of abdominal pain in pregnancy or unusual gynecologic pathology.

Overall rank: #6 of 7Overall rating: 3.6/5From $750/year Individual
6

Glass Health

AI Diagnostic Assistant

3.3(23)

Reasonable differential generation for gynecologic presentations. Lacks pregnancy-specific safety data, obstetric protocols, and the dual-patient awareness that OB/GYN CDS requires.

Overall rank: #5 of 7Overall rating: 3.8/5Free Beta / Enterprise Pricing TBD
7

DynaMed

Clinical Reference & Decision Support

2.9(19)

Covers common OB/GYN conditions with evidence-graded recommendations. Pregnancy drug safety data is available but less comprehensive than UpToDate/Lexicomp. Lacks the obstetric emergency protocol depth and ACOG guideline integration that OB/GYN physicians need.

Overall rank: #7 of 7Overall rating: 3.5/5From $399/year Individual

What Obstetrics & Gynecology Physicians Need from CDS Tools

Obstetric pharmacology is one of the most complex areas in clinical medicine. Most drugs lack robust pregnancy safety data β€” pregnant women are systematically excluded from clinical trials, leaving clinicians to rely on observational data, case reports, and animal studies. The Teratology Information Specialists (OTIS/MotherToBaby) database and individual drug safety profiles must be navigated for nearly every prescribing decision in pregnancy. CDS tools that provide current, evidence-based pregnancy safety data with clear risk-benefit framing are invaluable. Obstetric emergencies β€” eclampsia, postpartum hemorrhage, shoulder dystocia, cord prolapse, placental abruption β€” require protocol-driven responses where seconds matter. Magnesium sulfate dosing for eclampsia prophylaxis, oxytocin protocols for labor induction and PPH management, and the institutional massive transfusion protocol must all be instantly accessible. CDS tools that support these acute protocols complement the obstetric team's training and simulation preparation. Gynecology adds its own CDS complexity. ACOG practice bulletins cover over 200 clinical topics, from abnormal uterine bleeding workup to cervical cancer screening algorithms (updated in 2020 with risk-based management tables that are nearly impossible to memorize). Contraception counseling involves comparing 15+ methods across efficacy, side effect profiles, and patient-specific contraindications. Fertility evaluation and management, menopause hormone therapy decision-making, and gynecologic oncology treatment protocols round out the specialty's CDS needs.

Key Evaluation Criteria for Obstetrics & Gynecology

01Medication safety in pregnancy (PLLR data, teratogenicity risk assessment)
02Obstetric emergency protocols (eclampsia, PPH, shoulder dystocia)
03Prenatal screening and diagnostic testing algorithms (NIPT, quad screen, amnio criteria)
04Cervical cancer screening risk-based management tables (ASCCP 2019)
05Contraception comparison and patient-specific selection guidance
06ACOG practice bulletin integration (200+ clinical topics)

β€œEvery prescribing decision in pregnancy involves weighing risks to two patients simultaneously β€” mother and fetus. CDS tools that present this risk-benefit framework clearly can meaningfully improve the quality of obstetric pharmacotherapy.”

Dr. Mary D'Alton

Chair, Department of Obstetrics & Gynecology, Columbia University Irving Medical CenterΒ· AJOG, 2023