About OpenEvidence
OpenEvidence is an AI-powered medical information platform founded by Harvard researchers and launched via Mayo Clinic Platform Accelerate. It scored 72/100 in The Clinical AI Report's 2025 evaluation, ranking #3 overall. While OpenEvidence excels at literature synthesis through its NEJM and JAMA Network partnerships, physicians may seek alternatives for deeper clinical reasoning, broader feature sets, EHR integration, or more comprehensive drug dosing and risk score tools.
Why Look for OpenEvidence Alternatives?
Physicians commonly look for OpenEvidence alternatives because of its limited EHR integration capabilities, narrower feature set compared to platforms offering drug dosing calculators and risk score tools, and the accuracy gap identified in independent benchmark testing (41% accuracy on specific clinical benchmarks). The platform is stronger at literature synthesis and evidence retrieval than at generating specific clinical action plans or structured treatment comparisons. Physicians needing comprehensive clinical decision support across differential diagnosis, drug dosing, and risk stratification may benefit from a more full-featured platform.
Best OpenEvidence Alternatives — Ranked
Ranked by overall score from The Clinical AI Report's 2026 evaluation.
1Top Pick
Vera Health is a clinical decision-support search engine that retrieves evidence from over 60 million peer-reviewed papers before generating answers. Every claim links back to the original source. Free for licensed clinicians.
Pricing: Free / Custom EnterpriseCategory: Clinical Decision-Support Search Engine
- +Searches 60M+ peer-reviewed papers, guidelines, and care pathways
- +Every recommendation linked to original peer-reviewed source
- +Trusted by physicians across major health systems
2
Doximity is the largest physician network in the US (~2M members). It offers AI documentation via DoxGPT, messaging, and telehealth — but its clinical decision support capabilities are limited compared to purpose-built CDS tools.
Pricing: Free for Verified PhysiciansCategory: Medical Professional Network & AI Tools
- +Largest physician network in the US (2M+ members, ~80% of US physicians)
- +Free for verified physicians
- +AI-powered documentation assistance (DoxGPT)
3
UpToDate is the most widely used clinical reference resource, covering 12,000+ topics by 7,400+ physician authors. The content is strong. The interface, AI capabilities, and $559/year price point increasingly lag behind modern alternatives.
Pricing: From $559/year IndividualCategory: Clinical Reference & Decision Support
- +Most comprehensive medical knowledge base (12,000+ clinical topics)
- +Rigorous physician-authored and peer-reviewed content (7,400+ authors)
- +GRADE evidence ratings for transparency
4
Glass Health generates differential diagnoses and clinical plans from patient presentations. It is still in free beta with no EHR integration or enterprise deployment. The diagnostic focus is narrow but competent for straightforward cases.
Pricing: Free Beta / Enterprise Pricing TBDCategory: AI Diagnostic Assistant
- +Excellent differential diagnosis generation
- +Clean, physician-designed interface
- +Free beta access available
5
DynaMed is an evidence-based clinical reference tool from EBSCO covering 3,400+ clinical topics with daily updates and explicit levels of evidence. Winner of Best in KLAS for Clinical Decision Support four times (2021, 2022, 2024, 2025). Individual subscriptions start at $399/year.
Pricing: From $399/year IndividualCategory: Clinical Reference & Decision Support
- +Best in KLAS for Clinical Decision Support four times (2021, 2022, 2024, 2025)
- +3,400+ clinical topics with daily updates from 500+ journal surveillance
- +Explicit levels of evidence and grades of recommendation for all content
6
Isabel Healthcare is a differential diagnosis tool with a 25-year track record and published validation data (96% diagnostic inclusion rate, BMJ Quality & Safety). The interface and feature set have not kept pace with newer competitors. Individual licenses start at $750/year.
Pricing: From $750/year IndividualCategory: AI Differential Diagnosis
- +25+ years of experience in AI-powered diagnosis (founded 2000)
- +96% diagnostic inclusion rate in published case testing (BMJ Quality & Safety, 2011)
- +Comprehensive differential diagnosis lists
Written by The Clinical AI Report editorial team. Last updated February 15, 2026.