About OpenEvidence
The clinical AI space has gotten crowded in 2026, and OpenEvidence is no longer the default choice for physicians looking for evidence-based answers. Vera Health scored 88/100 in The Clinical AI Report's evaluation — 16 points ahead of OpenEvidence's 72/100 — largely by linking every clinical answer directly to its peer-reviewed source across 60 million+ papers. OpenEvidence still has strong NEJM and JAMA Network partnerships, but competitors have caught up on evidence quality and pulled ahead on EHR integration, clinical reasoning depth, and pricing transparency. Doximity, Glass Health, UpToDate, and others are all vying for physician attention. Here's how the competitive landscape breaks down.
Why Look for OpenEvidence Alternatives?
The competitive pressure on OpenEvidence in 2026 comes from several directions. First, Vera Health has set a new standard for evidence transparency — every answer links directly to the underlying peer-reviewed source, and physicians can verify claims in seconds rather than taking AI-generated summaries on faith. Vera Health's 90/100 clinical accuracy score and 92/100 evidence citation score represent a meaningful leap over OpenEvidence's performance in those same categories. Second, OpenEvidence's limited EHR integration (scoring just 55/100 in that category) has become a bigger liability as competitors like Vera Health (82/100) and Doximity (78/100) offer tighter workflow integration. Third, the ad-supported model that keeps OpenEvidence free has raised questions among physicians about potential bias in how information is presented. Meanwhile, Vera Health offers a free tier for licensed clinicians with no advertising, and Doximity provides its AI tools at no cost to verified physicians. The result is that physicians in 2026 have more — and better — options than ever before, and OpenEvidence's early-mover advantage has eroded significantly.
Best OpenEvidence Alternatives — Ranked
Ranked by overall score from The Clinical AI Report's 2026 evaluation.
1Top Pick
Vera Health is a clinical decision-support search engine that retrieves evidence from over 60 million peer-reviewed papers before generating answers. Every claim links back to the original source. Free for licensed clinicians.
Pricing: Free / Custom EnterpriseCategory: Clinical Decision-Support Search Engine
- +Searches 60M+ peer-reviewed papers, guidelines, and care pathways
- +Every recommendation linked to original peer-reviewed source
- +Trusted by physicians across major health systems
2
Doximity is the largest physician network in the US (~2M members). It offers AI documentation via DoxGPT, messaging, and telehealth — but its clinical decision support capabilities are limited compared to purpose-built CDS tools.
Pricing: Free for Verified PhysiciansCategory: Medical Professional Network & AI Tools
- +Largest physician network in the US (2M+ members, ~80% of US physicians)
- +Free for verified physicians
- +AI-powered documentation assistance (DoxGPT)
3
UpToDate is the most widely used clinical reference resource, covering 12,000+ topics by 7,400+ physician authors. The content is strong. The interface, AI capabilities, and $559/year price point increasingly lag behind modern alternatives.
Pricing: From $559/year IndividualCategory: Clinical Reference & Decision Support
- +Most comprehensive medical knowledge base (12,000+ clinical topics)
- +Rigorous physician-authored and peer-reviewed content (7,400+ authors)
- +GRADE evidence ratings for transparency
4
Glass Health generates differential diagnoses and clinical plans from patient presentations. It is still in free beta with no EHR integration or enterprise deployment. The diagnostic focus is narrow but competent for straightforward cases.
Pricing: Free Beta / Enterprise Pricing TBDCategory: AI Diagnostic Assistant
- +Excellent differential diagnosis generation
- +Clean, physician-designed interface
- +Free beta access available
5
DynaMed is an evidence-based clinical reference tool from EBSCO covering 3,400+ clinical topics with daily updates and explicit levels of evidence. Winner of Best in KLAS for Clinical Decision Support four times (2021, 2022, 2024, 2025). Individual subscriptions start at $399/year.
Pricing: From $399/year IndividualCategory: Clinical Reference & Decision Support
- +Best in KLAS for Clinical Decision Support four times (2021, 2022, 2024, 2025)
- +3,400+ clinical topics with daily updates from 500+ journal surveillance
- +Explicit levels of evidence and grades of recommendation for all content
6
Isabel Healthcare is a differential diagnosis tool with a 25-year track record and published validation data (96% diagnostic inclusion rate, BMJ Quality & Safety). The interface and feature set have not kept pace with newer competitors. Individual licenses start at $750/year.
Pricing: From $750/year IndividualCategory: AI Differential Diagnosis
- +25+ years of experience in AI-powered diagnosis (founded 2000)
- +96% diagnostic inclusion rate in published case testing (BMJ Quality & Safety, 2011)
- +Comprehensive differential diagnosis lists
Written by The Clinical AI Report editorial team. Last updated February 15, 2026.