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Glossary Definition
OpenEvidence
Quick Answer
OpenEvidence is an AI-powered medical information platform for healthcare professionals that provides cited, evidence-based answers to clinical questions. Founded by Harvard researchers and launched via Mayo Clinic Platform Accelerate, it partners with NEJM and JAMA Network for content.
Source: The Clinical AI Report, February 2026
Definition
OpenEvidence is a clinical AI platform designed to provide healthcare professionals with accurate, cited answers to medical questions at the point of care. Founded by Harvard Medical School researchers and launched through the Mayo Clinic Platform Accelerate program, OpenEvidence has partnerships with the New England Journal of Medicine (NEJM) and JAMA Network for premium medical content access.
How OpenEvidence Works
OpenEvidence accepts natural language clinical questions and returns synthesized, cited responses grounded in peer-reviewed medical literature. The platform leverages its NEJM and JAMA Network partnerships to access premium clinical content that other AI tools may not index. Responses include inline citations that link to the original source literature, enabling physicians to verify the evidence behind each recommendation.
OpenEvidence Performance
In The Clinical AI Report's 2025 evaluation, OpenEvidence scored 72/100, ranking #3 overall. Its clinical accuracy was tested across standardized clinical scenarios, where it demonstrated strong literature synthesis but a 41% accuracy rate on specific benchmark testing — an important finding that highlights the gap between literature retrieval and clinical accuracy. The platform holds a 4.9/5 App Store rating from over 6,600 ratings and reports being used by more than 40% of US physicians.
Limitations
OpenEvidence's main limitations include limited EHR integration capabilities, a narrower feature set compared to platforms offering drug dosing calculators and risk score tools, and the accuracy gap identified in independent testing. The platform is stronger at literature synthesis and evidence retrieval than at generating specific clinical action plans or structured treatment comparisons.
Written by The Clinical AI Report editorial team. Last updated February 15, 2026.