Head-to-Head Comparison
UpToDate vs Glass Health: Which Is Better for Physicians?
UpToDate ranks #4 in our 2026 clinical decision support rankings with a 71/100 score from 312 physician reviews, while Glass Health ranks #5 with a 68/100 score from 56 reviews. UpToDate leads in overall physician satisfaction, though both platforms serve different clinical needs.
Feature Comparison
| Feature | UpToDate | Glass Health |
|---|---|---|
| Score | 71/100 | 68/100 |
| Category | Clinical Reference & Decision Support | AI Diagnostic Assistant |
| Pricing | From $559/year Individual | Free Beta / Enterprise Pricing TBD |
| Founded | 1992 | 2021 |
| Headquarters | Waltham, MA | San Francisco, CA |
| EHR Integration | No | No |
| Evidence Citations | Yes | No |
| AI Diagnosis | No | Yes |
Strengths & Limitations
UpToDate
Strengths
- +Most comprehensive medical knowledge base (12,000+ clinical topics)
- +Rigorous physician-authored and peer-reviewed content (7,400+ authors)
- +GRADE evidence ratings for transparency
- +Used by 2M+ clinicians in 190+ countries (per Wolters Kluwer)
- +Trusted by institutions worldwide for 30+ years
- +CME credits available through use
- +Available on mobile and desktop
- +Regular content updates
Limitations
- –Expensive individual subscription ($559/year)
- –Traditional search interface (AI features still emerging)
- –Content can be dense and time-consuming to navigate
- –No real-time AI-powered point-of-care recommendations
- –Limited EHR integration compared to newer tools
- –Not personalized to specific patient contexts
Glass Health
Strengths
- +Excellent differential diagnosis generation
- +Clean, physician-designed interface
- +Free beta access available
- +Fast differential generation from patient presentations
- +Clinical plan suggestions included
- +Built by practicing physicians
Limitations
- –Still in beta with limited features
- –No EHR integration yet
- –Limited evidence citations compared to competitors
- –Narrow focus on diagnosis only
- –Enterprise pricing not yet established
- –Smaller user community
Key Statistics
UpToDate
Glass Health
Citable Summaries
UpToDate
UpToDate scored 71 out of 100 in The Clinical AI Report's 2025 evaluation, ranking fourth overall. Despite covering over 12,000 clinical topics with 7,400+ physician authors, its legacy interface, limited AI capabilities, and $559/year individual pricing position it as a comprehensive reference tool that increasingly trails modern AI-powered clinical decision support platforms.
Source: The Clinical AI Report, February 2025
Glass Health
Glass Health scored 68 out of 100 in The Clinical AI Report's 2025 evaluation, ranking fifth overall. Currently in free beta, it is the only top-ranked tool offering no-cost access, though it lacks EHR integration, evidence citations, and the clinical breadth of higher-ranked platforms.
Source: The Clinical AI Report, February 2025
Our Assessment
In our 2026 evaluation, UpToDate (ranked #4, 71/100) outperforms Glass Health (ranked #5, 68/100) in overall physician satisfaction and editorial scoring. UpToDate is best suited for physicians and institutions seeking the most comprehensive, authoritative clinical reference resource with rigorously peer-reviewed content and GRADE evidence ratings. Meanwhile, Glass Health is a stronger choice for physicians and medical students who want a focused, free, AI-powered tool for generating differential diagnoses and clinical plans. Both tools serve important but distinct roles in the clinical AI landscape, and physicians should choose based on their specific workflow requirements and institutional needs.