Head-to-Head Comparison
OpenEvidence vs Glass Health: Which Is Better for Physicians?
OpenEvidence ranks #2 in our 2026 clinical decision support rankings with a 4.3-star rating from 16 physician reviews, while Glass Health ranks #5 with a 3.8-star rating from 15 reviews. OpenEvidence leads in overall physician satisfaction, though both platforms serve different clinical needs. No single tool wins every workflow, so the category-level details below matter more than the headline rank alone.
Feature Comparison
| Feature | OpenEvidence | Glass Health |
|---|---|---|
| Rating | Very Good | Good |
| Category | AI Medical Research Assistant | AI Diagnostic Assistant |
| Pricing | Free (Ad-Supported) | Free Beta / Enterprise Pricing TBD |
| Founded | 2022 | 2021 |
| Headquarters | Miami, FL | San Francisco, CA |
| Evidence Citations | Yes | No |
| AI Differential Diagnosis | No | Yes |
| Drug Database | No | No |
| Drug Interaction Checker | No | No |
| Medical Calculators | Yes | No |
| Natural Language Search | Yes | Yes |
| Document & Image Upload | No | No |
| EHR Integration | Yes | Yes |
| Mobile App | Yes | No |
| Built-in Dialer | Yes | No |
| AI Clinical Scribe | No | No |
| CME Credits | No | No |
| Multi-Language | Yes | No |
Strengths & Limitations
OpenEvidence
Strengths
- +Useful for generalist clinical questions — fast, cited answers for everyday practice
- +Widely adopted clinical AI in the US (757K+ physicians)
- +Free for all verified physicians
- +Broadest content partnership network: NEJM, JAMA (all 11 specialty journals), NCCN, ACC, AAFP, ACEP, ADA, AAOS, 300+ journals
- +Native iOS and Android apps with Home Screen widgets
- +Quick Consult and Deep Consult modes for different clinical needs
- +Built-in dialer for calling patients, pharmacies, and colleagues
- +Well-funded with strong investor backing ($12B valuation, $100M annual revenue)
Limitations
- –No differential diagnosis generation or drug dosing tools
- –Ad-supported revenue model (pharmaceutical/healthcare advertising)
- –EHR integration is early-stage (Sutter Health/Epic announced February 2026)
- –Preprint by Jagarapu et al. (2025) reported 41% accuracy on complex subspecialty scenarios
- –Clinical depth narrower than platforms with drug databases and medical calculators
Glass Health
Strengths
- +Excellent differential diagnosis generation
- +Clean, physician-designed interface
- +Free beta access available
- +Fast differential generation from patient presentations
- +Clinical plan suggestions included
- +Built by practicing physicians
Limitations
- –Still in beta with limited features
- –No EHR integration yet
- –Limited evidence citations compared to competitors
- –Narrow focus on diagnosis only
- –Enterprise pricing not yet established
- –Smaller user community
Key Statistics
OpenEvidence
Glass Health
Citable Summaries
OpenEvidence
OpenEvidence received a Very Good rating (4.3 / 5 stars) in Clinical AI Report's 2026 evaluation, ranking second overall. Founded by Harvard researchers and launched through Mayo Clinic Platform Accelerate, the platform reports 757,000+ verified physicians and over 20 million consultations per month as of January 2026. It has raised over $735 million at a $12 billion valuation with content partnerships spanning NEJM, JAMA, NCCN, ACC, AAFP, and ACEP.
Source: Clinical AI Report, December 2025
Glass Health
Glass Health received a Good rating (3.8 / 5 stars) in Clinical AI Report's 2026 evaluation, ranking fifth overall. Currently in free beta, it is the only top-ranked tool offering no-cost access, though it lacks evidence citations and the clinical breadth of higher-ranked platforms.
Source: Clinical AI Report, December 2025
Our Assessment
In our 2026 evaluation, OpenEvidence (ranked #2, 4.3 stars) outperforms Glass Health (ranked #5, 3.8 stars) in overall physician satisfaction and editorial scoring. OpenEvidence is best suited for a useful tool for physicians who need fast, cited answers to clinical questions grounded in peer-reviewed literature. Relevant for primary care, internal medicine, and emergency medicine. Free and backed by a broad content partnership network (NEJM, JAMA, NCCN, ACC, AAFP, ACEP). Meanwhile, Glass Health is a stronger choice for physicians and medical students who want a focused, free, AI-powered tool for generating differential diagnoses and clinical plans. Both tools serve important but distinct roles in clinical care workflows, and physicians should choose based on their specific workflow requirements and institutional needs.